jMorp

Japanese Multi Omics Reference Panel, jMorp, is a database of metabolome and proteome data in plasma obtained from volunteers in ToMMo. Metabolome data were measured by proton NMR and LC-MS, and proteome data were obtained by nanoLC-MS. We could measure several thousands of metabolites including the uncharacterized ones, and several hundreds of proteins until now. The data will be released after careful check of each metabolite and protein in order.

Contact Us

jmorp [AT] omics [DOT] megabank [DOT] tohoku [DOT] ac [DOT] jp

Update History

Sep 25th, 2017: Bug Fix
The metabolites [MS] compound were filtered. In the case that if the same compound was identified in the same MS mode, a peak with more high intensity was selected, basically.

Augsut 31th, 2017: Bug Fix
Replaced GWAS results plot to the plot with data set reported in Scientific Reports 6, Article number: 31463 (2016) doi:10.1038/srep31463

August 10th, 2017: Major Update
We released distributions of concentrations of 37 metabolites identified by NMR detected in 5,093 volunteers, and distributions of peak intensities of 270 characterized metabolites by LC-MS in 1,312 volunteers.

June 26th, 2017: Minor Update
Correlation network viewer has been implemented, and plots for age dependency in each metabolites. Also GWAS (Genome Wide Association Studies) results for 5 compounds (TCN000004, TCN000017, TCN000019, TCN000031, TCN000033) as manhattan plots have added in each compound pages, which have been reported in Koshiba et al., Scientific Reports 6, Article number: 31463 (2016) doi:10.1038/srep31463

August 29th, 2016: Major Update
We released distributions of concentrations of 37 metabolites identified by NMR, distributions of peak intensities of 270 characterized metabolites by LC-MS, and correlation among metabolites detected in 1,008 volunteers. We also released observed peptides of 256 abundant proteins detected in 501 volunteers.

December 22nd, 2015: Minor Update
Searchbox autocompleting has been implemented. ItemTable is available to download as a tab-delimited text format.

July 23rd, 2015: Bug Fix
Renamed "ItemID" to "ToMMo Compound ID" on the Top page.

July 7th, 2015: Minor Update
The statistics table in "Histogram and Statistics" on the compound detail page has been colored.

July 2nd, 2015: Initial Release
We released distributions of concentrations of 37 metabolites identified by NMR, distributions of peak intensities of 201 characterized metabolites by LC-MS, and observed frequencies of 256 abundant proteins.

older version: Japanese Multi Omics Reference Panel 2015

Tohoku Medical Megabank Organization

Tohoku University Tohoku Medical Megabank Organization (ToMMo) was founded to establish an advanced medical system to foster the reconstruction from the Great East Japan Earthquake. The organization is developing a biobank that includes medical and genome information for supporting health and welfare in the tohoku area.

More details

Sample

The plasma metabolome [NMR] analysis of 5,093 volunteers, plasma metabolome [MS] analysis of 1,312 volunteers, and proteome analysis of 501 volunteers from the population-based cohort by Tohoku Medical Megabank Project.

Analytic Platform

Metabolites [NMR] Metabolites [MS] Proteins [MS]
NMR [600MHz]
CryoProbe
SampleJet
UHPLC-Q-TOF/MS
HPLC-Q-FT/MS
nanoLC-Q-FT-IT/MS
nanoLC-FT-IT/MS
nanoLC-Q-FT/MS

References

Application Result
Koshiba et al. "The structural origin of metabolic quantitative diversity", Scientific Reports 6, Article number: 31463 (2016) doi:10.1038/srep31463

Methods of MS metabolome
Saigusa et al. "Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery", PLoS ONE 11(8): e0160555 (2016)

Links

Artwarks

Designed by Kota Jin